Red cell folate (categories 3)
Red cell folate data available for STOP cohort only.
Over or below median (median level calculated in STOP) <14900 vs ≥14900.
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
314.979852
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
2.701767
|
1
|
0.1
|
ns
|
|
GA_samp
|
91.008623
|
1
|
<0.0001
|
***
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
33.967504
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
2.501515
|
1
|
0.1
|
ns
|
|
GA_samp
|
1678.317810
|
1
|
<0.0001
|
***
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
566.365724
|
1
|
<0.0001
|
***
|
|
rcfolate_gp3
|
4.710131
|
1
|
0.03
|
*
|
|
GA_samp
|
779.739710
|
1
|
<0.0001
|
***
|
Insulin (uU/ml)
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
1.930
|
1.930
|
0.2
|
ns
|
|
GA_samp
|
1
|
Inf
|
2.869
|
2.869
|
0.09
|
ns
|
HOMA-IR
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
1.630
|
1.630
|
0.2
|
ns
|
|
GA_samp
|
1
|
Inf
|
2.215
|
2.215
|
0.1
|
ns
|
Glucose (mmol/L)
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
rcfolate_gp3
|
1
|
Inf
|
2.315
|
2.315
|
0.1
|
ns
|
|
GA_samp
|
1
|
Inf
|
1.029
|
1.029
|
0.3
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
18.05 (13.12, 24.83)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.07 (0.99, 1.16)
|
0.10
|
|
GA_samp
|
1.13 (1.10, 1.16)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.70 (1.42, 2.03)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
0.96 (0.92, 1.01)
|
0.11
|
|
GA_samp
|
1.36 (1.34, 1.39)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.06 (0.05, 0.07)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
0.93 (0.88, 0.99)
|
0.03
|
|
GA_samp
|
1.33 (1.30, 1.36)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
8.07 (5.51, 11.81)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.08 (0.97, 1.20)
|
0.16
|
|
GA_samp
|
1.03 (1.00, 1.06)
|
0.09
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.74 (1.17, 2.61)
|
0.007
|
|
rcfolate_gp3≥14900
|
1.08 (0.96, 1.20)
|
0.20
|
|
GA_samp
|
1.03 (0.99, 1.06)
|
0.14
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
4.87 (4.56, 5.21)
|
<0.0001
|
|
rcfolate_gp3≥14900
|
1.02 (0.99, 1.04)
|
0.13
|
|
GA_samp
|
1.00 (0.99, 1.00)
|
0.31
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

Estimated marginal means
|
Outcome
|
rcfolate_gp3
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
PRL (ng/ml)
|
<14900
|
73.126
|
5.474
|
69.360
|
62.983
|
84.903
|
|
PRL (ng/ml)
|
≥14900
|
78.147
|
5.839
|
68.978
|
67.326
|
90.709
|
|
hPL (μg/ml)
|
<14900
|
59.412
|
1.867
|
67.936
|
55.800
|
63.258
|
|
hPL (μg/ml)
|
≥14900
|
57.204
|
1.797
|
67.858
|
53.728
|
60.904
|
|
GH2 (ng/ml)
|
<14900
|
1.495
|
0.051
|
100.542
|
1.397
|
1.600
|
|
GH2 (ng/ml)
|
≥14900
|
1.396
|
0.048
|
100.355
|
1.304
|
1.493
|
|
Insulin (uU/ml)
|
<14900
|
11.221
|
0.408
|
Inf
|
10.449
|
12.050
|
|
Insulin (uU/ml)
|
≥14900
|
12.091
|
0.474
|
Inf
|
11.196
|
13.057
|
|
HOMA-IR
|
<14900
|
2.371
|
0.092
|
Inf
|
2.198
|
2.558
|
|
HOMA-IR
|
≥14900
|
2.549
|
0.105
|
Inf
|
2.351
|
2.764
|
|
Glucose (mmol/L)
|
<14900
|
4.717
|
0.037
|
Inf
|
4.646
|
4.789
|
|
Glucose (mmol/L)
|
≥14900
|
4.802
|
0.043
|
Inf
|
4.720
|
4.886
|
Post-hoc comparisons
|
Outcome
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥14900 / <14900
|
1.07 (0.99, 1.16)
|
0.1
|
|
hPL (μg/ml)
|
≥14900 / <14900
|
0.96 (0.92, 1.01)
|
0.1
|
|
GH2 (ng/ml)
|
≥14900 / <14900
|
0.93 (0.88, 0.99)
|
0.03
|
|
Insulin (uU/ml)
|
≥14900 / <14900
|
1.08 (0.97, 1.20)
|
0.2
|
|
HOMA-IR
|
≥14900 / <14900
|
1.08 (0.96, 1.20)
|
0.2
|
|
Glucose (mmol/L)
|
≥14900 / <14900
|
1.02 (0.99, 1.04)
|
0.1
|